Research Interests:
Bioinformatics|Mass Spectreometry-based Proteomics

Mass spectrometry (MS) is the key experimental method for large-scale protein identification. My research contributes to the technologies for mass spectra data analysis. To be more specific, my research is to develop algorithms and softwares to identify tandem mass (MS/MS) spectra.
I'm currently research on crosslinking proteomics, which means chemical crosslinking coupled with mass spectrometry. With CXMS, protein structure and protein interaction can be effectively studied.

Software tools

pXtract, a software to creates .DTA、.MGF and .MS2 input files directly from Thermo Scientific .raw LC-MS/MS data files.

pLink, a software dedicated for the analysis of chemically cross-linked proteins or protein complexes using mass spectrometry.


  [1] FAN Sheng-Bo, MENG Jia-Ming, LU Shan, ZHANG Kun, YANG Hao, SUN Rui-Xiang, DONG Meng-Qiu and HE Si-Min. Using pLink to Analyze Cross-Linked Peptides Current Protocols. 2014.

  [2] FAN Sheng-Bo, WU Yan-Jie, YANG Bing, CHI Hao, MENG Jia-Ming, LU Shan, ZHANG Kun, WU Long, SUN Rui-Xiang, DONG Meng-Qiu and HE Si-Min. A new approach to protein structure and interaction research: Chemical Cross-linking in Combination with Mass Spectrometry Prog. Biochem. Biophys. 2014.

  [3] Bing Yang, Yan-Jie Wu, Ming Zhu, Sheng-Bo Fan, Jinzhong Lin, Kun Zhang, Shuang Li, Hao Chi, Yu-Xin Li, Hai-Feng Chen, Shu-Kun Luo, Yue-He Ding, Le-Heng Wang, Zhiqi Hao, Li-Yun Xiu, She Chen, Keqiong Ye, Si-Min He and Meng-Qiu Dong. Identification of cross-linked peptides from complex samples. Nature Methods, doi:10.1038/nmeth.2099.

  [4] ZHANG Kun, WANG Le-Heng, CHI Hao, BU De-Chao, YUAN Zuo-Fei, LIU Chao, FAN Sheng-Bo, CHEN Hai-Feng, ZENG Wen-Feng, LUO Hai-Tao, SUN Rui-Xiang, HE Si-Min, XIE Lu, ZHAO Yi. Proteogenomics: Improving Genomes Annotation by Proteomics. Prog. Biochem. Biophys. 2013, 40(4):297-308.


I received my bachelor's degree in Department of Software Engineering in 2009 from Beijing University of Aeronautics and Astronautics.

I am currently studying for master's degree in Graduate University of Chinese Academy of Scineses, and supervised by associate professor Ruixiang Sun at Institute of Computing Technology.

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